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Publications and Presentations

Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS

Chunling Duan, Moorim Kang, Xiaojie Pan, Zubao Gan, Vera Huang, Guanlin Li, Robert F. Place, Long-Cheng Li (2023) Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS. Preprint, DOI: 10.1101/2023.02.27.530262

Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells.

Yong-Li Zhang, Moorim Kang, Jian-Cheng Wu, Meng-Yao Xie, Ruo-Yan Xue, Qi Tang, Hua Yang & Long-Cheng Li (2022) Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells. Bioengineered, 13:3, 6729-6739, DOI: 10.1080/21655979.2022.2045835

Small activating RNA induced expression of VHL gene in renal cell carcinoma.

Kang MR, Park KH, Lee CW, Lee MY, Han SB, Li LC, Kang JS. Small activating RNA induced expression of VHL gene in renal cell carcinoma. Int J Biochem Cell Biol. 2018 Feb: S1357-2725(18)30030-X.

saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.

Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell Res. 2016 Feb 23.

Inducing gene expression by targeting promoter sequences using small activating RNAs.

Wang J, Place RF, Portnoy V, Huang V, Kang MR, Kosaka M, Ho MK, Li LC. Inducing gene expression by targeting promoter sequences using small activating RNAs. J Biol Methods. 2015 Mar 11; 2(1).

Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells.

Wang J, Huang V, Ye L, Bárcena A, Lin G, Lue TF and Li LC. Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells. Stem Cell Dev 2014 Sep 18.

Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation.

Wang X, Wang J, Huang V, Place RF, and Li LC. Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Biochem J 2012 May 1; 443(3):821-8.

Small activating RNA-guided iNOS up-regulation improves erectile function of diabetic rats

Wang T, Li M, Yuan H, Zhan Y, Xu H, Wang S, Yang W, Liu J and Li LC. Small activating RNA-guided iNOS up-regulation improves erectile function of diabetic rats. J Urol 2013 Aug; 190(2):790-8.

Targeted p21 WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells.

Kosaka M, Kang MR, Yang G and Li LC. Targeted p21 WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells. Nucleic Acid Ther 2012 2012 Oct; 22(5):335-43.

Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth

Kang MR, Yang G, Place RF, Charisse K, Epstein-Barash H, Manoharan H and LI LC. Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth. Cancer Res 2012 Oct 1;72(19):5069-79.

Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth.

Ren S, Kang MR, Wang J, Huang V, Place RF, Sun Y, Li LC. Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth. Prostate. Oct; 73(14):1591-601.

Formulation of small activating RNA into lipidoid nanoparticles inhibits xenograft prostate tumor growth by inducing p21 expression

Place RF, Wang J, Noonan E, Meyers R, Manoharan M, Charisse K, Duncan R, Huang V, Wang X and Li LC. Formulation of small activating RNA into lipidoid nanoparticles inhibits xenograft prostate tumor growth by inducing p21 expression. Molecular Therapy – Nucleic Acids 2012; e15.

Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells.

Chen Z, Place RF, Jia ZJ, Pookot D, Dahiya R, Li LC. Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells. Mol Cancer Ther. 2008 Mar;7(3):698-703.

MicroRNA-373 induces expression of genes with complementary promoter sequences.

Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13. Epub 2008 Jan 28.

Small double-stranded RNAs induce transcriptional activation in human cells.

Li LC, Okino ST, Zhao H, Pokot D, Place RF, Dahiya R. Small double-stranded RNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA. 2006 Nov 14;103(46):17337-17342.

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