Join Us
We are Seeking Talented Individuals
Ractigen is interested in candidates at all career levels whom have a belief that oligonucleotides will be an emergent,
breakthrough drug class of the future. We are seeking talented individuals who work well within a team and like to
push the envelope of science.
Current Job Openings
Please review the available positions below. If interested, use the provided link to submit a cover letter and résumé/CV for consideration.
Don’t See What You’re Looking For?
If a specific position of interest is not listed but find yourself still determined on working with us, please send an inquiry and résumé/CV using our general submission form.
Translational Development
This position will be responsible for translational development of Ractigen’s drug programs throughout the non-clinical process into clinical development. This position will be expected to lead a team of translational scientists to design, validate, and execute translational plans, as well as work closely with Drug Discovery and Early Drug Development teams to provide input on assay development and experimental design.
Job location
Suzhou city, Jiangsu Province, China
Report to
This position reports directly to CEO.
Responsibilities
- Under the leadership of the senior management team, develops the strategy and leads company efforts in translational sciences (transition of the organization’s drug discoveries into early stage and late-stage development programs) including in vivo Pharmacology and IND enabling studies.
- Provides leadership to the PK, Biomarker, Pharmacology, and Toxicology groups, nurturing a culture of engagement, respect and high performance within a team environment. Provides leadership, coaching and feedback; mentors and empowers personnel.
- Conceives and executes translational strategies to support advancing discovery projects into clinical development programs; providing the link between early research and the clinical.
- Oversees design of proof-of-concept studies and full development for various therapeutic area programs.
- Develops, manages and implements operating budget for non-clinical IND projects, ensuring the financial resources are effectively allocated and managed to support achievement of the strategic objectives.
- Participates as a key member of Ractigen R&D Leadership team.
- Establish milestones, timelines, workflows and make sure projects’ milestones and major objectives are met.
- Oversee translational development by helping research teams develop robust translational data packages to support early clinical proof-of-concept, as well as research needs of post-POC clinical programs.
- Work closely with Preclinical Development and analytical teams to provide input on lead compound development and design of mechanism of action studies.
- Guide in-house pharmtox studies.
- Guide non-clinical and clinical pharmacology to determine FIH dose and schedule, development/execution of plans to analyze PK, drug metabolism, pharmacodynamics, etc.
- CMO/CRO selection, audit, and management including acquiring quotes/cost estimates for GLP and non-GLP studies, resolving issues that may rise during contracted work, coordination between multiple contractors, etc.
- Responsible for drafting clinical study-related and regulatory documents such as IND applications, Clinical Study Reports, IBs, etc.
- Communicate with regulatory agencies in regards to pharmtox or other aspects of the Pre-IND/IND process.
- Participate in the development of clinical trial protocols, facilitate smooth transition to clinical teams and execute clinical programs.
- Responsible for establishing and improving R&D quality management system, including but not limited to, various rules, policies and SOPs.
- Ad hoc assignments by supervisors.
Requirements
- Demonstrated ability to think holistically and long-term across a broad spectrum of industry trends and issues. Ability to envision, shape and communicate long term business objectives and priorities and be able to create competitive and break-through strategies and plans.
- Excellent analytical and conceptual thinking abilities, forward-looking. Out-of-the-box problem solving skills.
- Proven history of building relationships and fostering engagement across multiple stakeholders, including the board, senior management, operational levels, suppliers and business partners.
- Exceptional leadership skills and the ability to mentor and develop strong contributors. A track record of inspiring and aligning organizations around goals and contributing as an active role model in company values.
- Experience collaborating with biologists and chemists to generate in vivo target validation data and establishing PK/PD and biomarker correlations.
- Experience with identifying relevant translational disease models and applying them to meet program goals.
- Multiple examples of partnering with drug discovery to identify and develop candidates.
- Strong track record of meeting and exceeding goals. Demonstrated ability to drive steep change as well as incremental, continuous improvements in quality, efficiency and growth through change initiatives and vigorous leadership.
- Sound business acumen with a practical, results-oriented leadership style that can translate innovate, creative strategies and conceptual thinking into action plans.
- Demonstrated high level of integrity and ethics.
- PhD/MD degree in Translational Medicine, pharmacology and related field.
- 10+ years’ industrial experience or an equivalent combination of education and experience.
VP, Neuroscience
This position will lead the overall strategy, planning, and execution of drug programs for Neurodegenerative and Neuromuscular diseases from discovery to clinical trial and be responsible for championing and overseeing the work of drug discovery and preclinical development across all stages of drug development. The candidate is expected to be a strategically minded, hands-on preclinical development and early clinical development expert with the responsibility for transitioning projects from research into clinic development, and for the translational and early clinical development strategy for specific diseases. A mix of strong disease knowledge, cutting edge science, but enough early development experience to be able to be autonomous when driving programs into the clinic and through the regulatory process are required.
Job location
Shanghai, China
Reporting to
This position reports to the CEO
Responsibilities
- Build and manage an engaged and entrepreneurial team to implement company’s strategic vision in the Neurodegenerative and Neuromuscular field through the development of novel platforms, advancement of the internal portfolio, and delivery of differentiated development candidates.
- Build a strong portfolio of oligonucleotide drug programs in the strategic Neurodegenerative and Neuromuscular space.
- Provide scientific and medical leadership and preclinical development expertise on cross-functional Project Teams.
- Provide guidance and direct input into strategy, planning and contents of preclinical development plan as well as key components of regulatory submissions.
- Provide clear and timely communication and interpretation of study results to organizational governance.
- Engage with external scientific and medical experts to bring insight to development programs.
- Develop early clinical development plans that are innovative, safe and create a foundation for decision making.
- Be responsible for Phase 0, First-in-Human, Proof-of-Mechanism and Phase 1 studies throughout development, including validation of innovative clinical biomarkers to support decision making.
- Lead collaborative efforts with academic labs and external CROs to drive new technologies and execute on project deliverables for programs.
- Foster relationships with patient advocacy organizations, policy makers, regulatory and other organization.
- Be a critical element in company’s approach to create an effective bridge between discovery research and clinical development.
- Keep upper management informed of key opportunities, benefit/risk issues for the assigned therapeutic areas.
- Working effectively on a cross-functional team to facilitate out-licensing opportunities to bring value to company.
- Follow important developments and relevant trends in the scientific literature and develop/maintain contacts with external experts to support understanding of the candidate drug effects and to gain strategic insights to the further development of study and overall program.
Requirements
- MD or PhD and at least 8+ years of broad bio/pharmaceutical industry experience in drug development, coupled with at least 3+ years of experience of leading projects in industry from preclinical development to clinical.
- Strong record of basic and/or translational research productivity.
- Early clinical development experience in an industry setting is a plus.
- Strong expertise in Neurodegenerative and Neuromuscular diseases with at least some experiences that range from Discovery through Clinical POC.
- Experience with first-in-class clinical trial design, patient selection, regulatory discussion, and a programmatic approach to learn about a new mechanism in the clinic.
- Proven experience leading teams in the development of small molecules through preclinical development, IND filing, and initiation of clinical trials.
- Experience with developing oligonucleotide-based therapeutics is a plus.
- Proven ability to effectively build alliances across functions, based on end-to-end drug development thinking and experience.
- Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific teams.
- Leadership skills in proactive strategy setting, priority evaluations, adapting to changes, conflicts resolutions, and effective partnership.
- Ability to communicate effectively in English, the shared language of our multicultural team.
VP, Chemistry and Pharmaceutical Development
The successful candidate will lead the Chemistry and Pharmaceutical Development teams and will provide preclinical research and GMP development direction of effective strategies implementation to support research and preclinical program activities, clinical trials, regulatory filings, and commercialization of company’s products. Reporting to CEO, the Vice President of Chemistry and Pharmaceutical Development will be responsible for developing and maintaining external partners and suppliers and part of the Company’s management team.
Job location
Suzhou city, Jiangsu Province, China
Reporting to
This position reports to CEO
Responsibilities
- Effectively leads chemistry research and development, in-house and external CMC activities and related functional resources.
- Effectively mentors, coaches, and manages the Pharmaceutical Development and Chemistry teams.
- Works with the Chemistry team to creatively design and synthesize complex oligonucleotide structures.
- Propose and implement the design of novel nucleosides, linkers, backbone modifications and conjugates that improve drug-like properties of oligonucleotides and their extrahepatic delivery.
- Responsible for the development of comprehensive manufacturing strategies and quality control for company’s oligonucleotide drugs.
- Ensures compliance with regulatory requirements for CMC regulatory submissions.
- Oversees Manufacturing Process Documentation, Investigator Brochures, Clinical Study Protocols, and Clinical Trial Documentation for compliance with cGMP, cGLP, and other appropriate regulations and guidelines for CMC-related issues.
- Ensures adherence to timelines and project alignment to meet group and company goals.
- Interacts with key scientific, preclinical and clinical research personnel within and outside Company to ensure timely and accurate regulatory compliance on CMC matters.
- Manages Chemistry team to ensure timely production of research oligos for various preclinical programs.
- Works closely with the Quality Control team to identify and resolve any relevant CMC issues.
Requirements
- Requires a Ph.D. in chemistry or related field and strong specialization in oligonucleotide-based space
- 8 or more years’ experience in industry relating to chemical synthesis, process development and CMC with successful IND/NDA submissions and commercialization of products; experience with siRNA/Oligonucleotide is required.
- Clear understanding and expertise in lead ID, lead optimization, SAR and clinical candidate success criteria
- Direct relevant experience in all aspects of development of oligonucleotide therapeutics.
- Direct relevant experience in method development and validation and use of appropriate analytical methodologies for oligonucleotide-based therapeutics.
- Experience with CMC regulatory aspects for oligonucleotide therapeutics.
- Proven leadership experience for the Research and Development function in a biopharmaceutical company.
- Excellent analytical, presentation, and writing skills are required.
- Senior managerial experience in a small company environment is desirable.
- Excellent interpersonal skills and ability to work efficiently and productively in a highly dynamic environment.
- Knowledge of cGMP, cGLP, ICH, USP and FDA guidelines and regulations.
Associate Director/Director for PharmTox
This position is responsible for toxicity studies of company’s preclinical drug programs for IND application of FDA and NMPA. Responsibilities include but are not limited to making and executing toxicity study plans, coordinating CMO and CRO activities, setting timelines and milestones to ensure timely execution of toxicity plan for IND programs.
Working locations
Suzhou city, Jiangsu Province, China
Report to
This position reports directly to VP, Translational Development.
Responsibilities
- Plan, lead, and execute toxicity study for IND projects. Developing and executing high quality, timely, integrated and scientifically sound toxicity strategies for IND submission.
- Develop and manage a PharmTox budget and timeline for IND projects.
- Establish milestones, timelines, workflows and make sure projects’ milestones and major objectives are met.
- Analyze the toxicity data to determine FIH dose and schedule, development/execution of plans to analyze PK, drug metabolism, pharmacodynamics, etc.
- CMO/CRO selection, audit, and management including acquiring quotes/cost estimates for GLP and non-GLP studies, resolving issues that may rise during contracted work, coordination between multiple contractors, etc.
- Draft and modify toxicology study-related and regulatory documents such as CTD for IND applications, IBs, etc.
- Communicate and interact with regulatory agencies regard to pharmtox or other aspects of the Pre-IND/IND process
- Work close with other functions such as DMPK, biology, CMC and clinical development.
- Ad hoc assignments by supervisors. Guide in-house pharmtox studies.
Requirements
- PhD degree in pharmacology or toxicology with more than 5 years of relevant working experiences.
- Track record of at least 2 successful IND filings.
- Deep knowledge about drug development process especially in toxicity, pharmacology. Quite familiar with regulatory policies e.g., ICH guidelines et al, for IND filing of FDA/NMPA.
- Excellent leadership, decision-making and judgment skills, good management and communication skills.
- Working experiences in big pharma companies is preferred.
- Experience in small nucleic acid drug development is a plus.
- Excellent skill in English writing and oral communication.
